Basic Information
VIS ID
TVIS10007703
Fusion event
HBV-OR2S1P integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2743
Orient
-
Integrated sequence
TGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGA| |CACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATC
Host Sequence
Chromosome
chr9
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
36013525/36013528 (Hg38)
End
36013525/36013528 (Hg38)
Orient
+
Location type
Intronic
Target gene
OR2S1P
Nearest miRNA
hsa-mir-101-2/Upstream/280533; hsa-let-7a-1/Downstream/810011;
Nearest TSS
ENST00000422679/Upstream/55374; ENST00000475774/Downstream/22905;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/41079, chr9-CpG: 73/Downstream/23273
Nearby gene
OR2S2(-55374) ; RECK(+23385) ;
Upstream sequence
ttatctggatcctttgcctttccatataaactttagagtcatcttattgatatccacaaaatagcttactgggattatgattgggattgcaatcaatctg
Downstream sequence
TGGCTTTTGATCACTACCTGGACATGTGCAACCCCCTTAGGTACCCTGTGGTCATGAGCAAGGCTGCCTACATGCCCATGGCTGTTGGCTCCTGGGCAGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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