Basic Information
VIS ID
TVIS10007704
Fusion event
HBV-LOC389765 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1958
Orient
+
Integrated sequence
CTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTT| |GCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCAT
Host Sequence
Chromosome
chr9
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
88427530/85812615 (Hg38)
End
88427530/85812615 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
LOC389765
Nearest miRNA
hsa-mir-101-2/Upstream/1842758; hsa-let-7a-1/Downstream/2933221;
Nearest TSS
ENST00000422679/Upstream/19135; ENST00000416045/Downstream/128531;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/6526, chr9-CpG: 100/Downstream/128171
Upstream sequence
gactcccaccatccccaagcagtaatgacgagcccccatctcatgtgttaacagagatttagtggggaaaccagagttctacccctacctgccagtaaca
Downstream sequence
aagatggattaaagatttaaacgttagacctaaaaccataaaaaccctagaagaaaacctaggcattaccattcaggacataggcgtgggcaaggacttA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate