Basic Information
VIS ID
TVIS10007708
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1958
Orient
+
Integrated sequence
CTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTT| |GCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCAT
Host Sequence
Chromosome
chrX
Cytoband
q25
Reference genome
GRCh37/hg19
Start
126501073/127367090 (Hg38)
End
126501073/127367090 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/5996037; hsa-mir-105-1/Downstream/6802288;
Nearest TSS
ENST00000429181/Upstream/547326; ENST00000486673/Downstream/295440;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/785752, chrX-CpG: 50/Downstream/2155784
Nearby gene
PRR32(-545305) ; ACTRT1(+683868) ;
Upstream sequence
TTCCAGTAGTAAACTGAACTAGATACTGTGAAGACACTTCCAGTTAATACCAAAACTAGGTCTTGGATGAAATAATTGTTATTGAACCAATGACACTGAA
Downstream sequence
aagatggattaaagatttaaacgttagacctaaaaccataaaaaccctagaagaaaacctaggcattaccattcaggacataggcgtgggcaaggacttc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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