VISDB Viral Integration Site DataBase

VIS ID

TVIS10007711

Fusion event

HBV-AFF2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2018

Orient

+

Integrated sequence

ATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCG| |GGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTG

Chromosome

chrX

Cytoband

q28

Reference genome

Start

End

148054369/148972839 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

FRAXE ; FRAXF

Target gene

miRNAs that regulate target gene

hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-3175 ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-4786-5p ; hsa-mir-6794-5p ; hsa-mir-4716-3p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-6502-3p ; hsa-mir-877-5p ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-2113 ; hsa-mir-3177-5p ; hsa-mir-143-5p ; hsa-mir-3944-5p ; hsa-mir-511-3p ; hsa-mir-4783-5p ; hsa-mir-3180-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-22-5p ; hsa-mir-5584-3p ; hsa-mir-488-5p ; hsa-mir-4773 ; hsa-mir-148a-5p ; hsa-mir-933 ; hsa-mir-1976 ; hsa-mir-26a-1-3p ; hsa-mir-26a-2-3p ; hsa-mir-3653-5p ; hsa-mir-370-3p ; hsa-mir-4279 ; hsa-mir-4720-3p ; hsa-mir-4804-3p ; hsa-mir-548aa ; hsa-mir-548ap-3p ; hsa-mir-548as-3p ; hsa-mir-548at-3p ; hsa-mir-548ay-3p ; hsa-mir-548t-3p ; hsa-mir-645 ; hsa-mir-6893-3p

Nearest miRNA

hsa-let-7f-2/Upstream/1688111; hsa-mir-105-1/Downstream/1255165;

Nearest TSS

Nearest CpG islands

None/Target, chrX-CpG: 62/Upstream/471076, chrX-CpG: 17/Downstream/498181

Upstream sequence

GATAGATTCTCTATACTTAAATTTGACTCCAGATGCTTTCAGTCACATTTAATAATTTCCATATTCTAACAGCATTATATTTGCTGCAGAAAAATATTCA

Downstream sequence

gtccttgcccacgcctatgtcctgaatggtaatgcctaggttttcttctagggtttttatggttttaggtctaacgtttaaatctttaatccatcttgaa