Basic Information
VIS ID
TVIS10007712
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2326
Orient
-
Integrated sequence
ACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAA| |CACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAG
Host Sequence
Chromosome
chrX
Cytoband
q28
Reference genome
GRCh37/hg19
Start
153483642/154218173 (Hg38)
End
153483642/154218173 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRAXE ; FRAXF
Nearest miRNA
hsa-let-7f-2/Upstream/198184; hsa-mir-1184-1/Downstream/232147;
Nearest TSS
ENST00000429181/Upstream/28115; ENST00000488220/Downstream/1583;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/80974, chrX-CpG: 32/Downstream/77215
Nearby gene
OPN1MW(-21290) ; OPN1MW2(+1561) ;
Upstream sequence
AGGGCTCATCCCCTGTACATCAGCTAGCAGGTTGGCAGCAAGACCAATCCCAGGCTGTGGCTGCTGGAGGAACAGGAGAAATCATGGGTTTCTGCCTTGG
Downstream sequence
gcatggtggcacacacctgtaatcccagctactggggaggctgaggcaggagaattgcttgagccggggagacggaggttgcagtgagccgagactgcgc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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