Basic Information
VIS ID
TVIS10007714
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1958
Orient
+
Integrated sequence
CTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTT| |GCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCAT
Host Sequence
Chromosome
chrX
Cytoband
p22.12
Reference genome
GRCh37/hg19
Start
20354891/20336773 (Hg38)
End
20354891/20336773 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-23c/Upstream/319586; hsa-let-7f-2/Downstream/8158782;
Nearest TSS
ENST00000429181/Upstream/18990; ENST00000636971/Downstream/106553;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/68080, chrX-CpG: 163/Downstream/1036944
Nearby gene
RPS6KA3(-70141) ; CNKSR2(+1037645) ;
Upstream sequence
gcaaagataaataggttggactaaatacaaagataataggtgggactattaaaacaaaagccaagataataggtgggactattaaactaaagagcctctg
Downstream sequence
aagatggattaaagatttaaacgttagacctaaaaccataaaaaccctagaagaaaacctaggcattaccattcaggacataggcgtgggcaaggacttc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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