Basic Information
VIS ID
TVIS10007727
Fusion event
HBV-chrY integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2081
Orient
+
Integrated sequence
TACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCT| |TTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATG
Host Sequence
Chromosome
chrY
Cytoband
q11.221
Reference genome
GRCh37/hg19
Start
15292176/13180275 (Hg38)
End
15292176/13180275 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-3690-2/Upstream/8574047; hsa-mir-12120/Downstream/298902;
Nearest TSS
ENST00000430575/Upstream/264779; ENST00000284856/Downstream/299229;
Nearest CpG islands
None/Target, chrY-CpG: 62/Upstream/274888, chrY-CpG: 33/Downstream/299104
Nearby gene
DDX3Y(-259786) ; UTY(+68083) ;
Upstream sequence
tggtagtttcttttgctgtgcagaagctctttagtttaattagatcccatttgtcaattttggcttttgttgccattgcttttggtgttttggacatgaa
Downstream sequence
aagggatccagtttcagctttctacatatggctagccagttttcccagcaccatttatttaatagggaatcctttccccattgcttgtttttctcaggtt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate