Basic Information
VIS ID
TVIS10007737
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1825
Orient
-
Integrated sequence
TAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTT| |TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGA
Host Sequence
Chromosome
chr15
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
45651409/45359211 (Hg38)
End
45651409/45359211 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10393/Upstream/641318; hsa-mir-11181/Downstream/73839;
Nearest TSS
ENST00000557528/Upstream/79960; ENST00000617932/Downstream/6859;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/160157, chr15-CpG: 114/Downstream/18561
Nearby gene
SLC28A2(-83277) ; GATM(+1913) ;
Upstream sequence
TACACACTGCTACAGATCAGGTAGGCAAATGAATTGTTGTAAAGTTAGTTCAAATATATGAGAAAGCTTATGATAGAATTTTTGGTTGGTTGAGCTATCT
Downstream sequence
GTATAAGTCCAAACCAACTGGTTATTAAAAATGTGTGGAATCTGTATGTACATTTTGATTATCTATTTGATTATATGATATTGCAAAGCAAGTGGTAGCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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