Basic Information
VIS ID
TVIS10007739
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1592
Orient
-
Integrated sequence
CCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCT| |TCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGAC
Host Sequence
Chromosome
chr16
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
90213874/90147466 (Hg38)
End
90213874/90147466 (Hg38)
Orient
+
Location type
Intronic
Target gene
FAM157C ; LOC105376781
Nearest miRNA
hsa-mir-11401/Upstream/1431129;
Nearest TSS
ENST00000527434/Upstream/21444; ENST00000566898/Downstream/10466;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/40949, chr16-CpG: 34/Downstream/23866
Nearby gene
PRDM7(-71536) ;
Upstream sequence
AGAGCCAGTGTGAtatcgggggaaattcacccctgatatttcatgtaggttcttttctattttccctgagtgtcagccagtctgagaaataaagggaaag
Downstream sequence
agtacaaaagagagaaattttaaagctggatgtccaggggagacatcacacgtcggcaggttccgtgatgccccccaagccgcaaaaccaacaagttttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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