Basic Information
VIS ID
TVIS10007743
Fusion event
HBV-LOC101928344 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1592
Orient
-
Integrated sequence
CCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCT| |TCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGAC
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
220388/220388 (Hg38)
End
220388/220388 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
LOC101928344
Nearest miRNA
hsa-mir-1302-11/Upstream/148278; hsa-let-7e/Downstream/584552;
Nearest TSS
ENST00000633603/Upstream/43492; ENST00000591533/Downstream/31183;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/149044, chr19-CpG: 70/Downstream/46697
Nearby gene
PLPP2(+60656) ;
Upstream sequence
aaacttgttggttttgcggcttggggggcatcacggaacctgccgacgtgtgatgtctcccctggacatccagctttaaaatttctctcttttgtactct
Downstream sequence
ttccctttatttctcagactggctgacactcagggaaaatagaaaagaacctacatgaaatatcaggggtgaatttcccccgataTCACACTGGCTCTTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate