AGTR1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007745
Fusion event
HBV-AGTR1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1868
Orient
+
Integrated sequence
TTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCA| |AGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGAC
Host Sequence
Chromosome
chr3
Cytoband
q24
Reference genome
GRCh37/hg19
Start
148452725/148734938 (Hg38)
End
148452725/148734938 (Hg38)
Orient
+
Location type
Intronic
Target gene
AGTR1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-410-3p ; hsa-mir-34a-5p
Nearest miRNA
hsa-let-7g/Upstream/14297032; hsa-mir-1224/Downstream/2830938;
Nearest TSS
ENST00000440867/Upstream/4758; ENST00000402260/Downstream/4860;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/36793, chr3-CpG: 102/Downstream/256351
Nearest cancer related gene
AGTR1(TSG, No orient, 0)
Upstream sequence
ctgcctccactcatggggggagccagtgtgtgcagagtccacacagggagagagaaagcaggagagaggcagggaaggtgctaggttccctgcggggtgc
Downstream sequence
AGAGATGAAATGGACGAAGCAGGCATGGAAACTGCCCTTCCTGCCTTAAATACAGAATGCCAGATCACAGCTCTGAATAAAAGTTAAGACCACATTGGGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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