AUTS2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007749
Fusion event
HBV-AUTS2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1451
Orient
+
Integrated sequence
ATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCT| |GCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCC
Host Sequence
Chromosome
chr7
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
69945506/70480520 (Hg38)
End
69945506/70480520 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
AUTS2
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-222-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1183/Upstream/3366123; hsa-mir-10399/Downstream/827152;
Nearest TSS
ENST00000635602/Upstream/163604; ENST00000489774/Downstream/115565;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/880469, chr7-CpG: 64/Downstream/115328
Upstream sequence
acttataatttggagctaaacattgggtacacatggacataatgatgggtacaataaacactggggactccaaaagagggagagagagggcaaaagttga
Downstream sequence
CAATCCATAAGGGGAATGCACCTGGTCATCTTTTCCTGAGCATCTTGGGATCAGGTGCTCTTGGGAATAAGATGATACGTATACCCAAGAGCACTTGATC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate