Basic Information
VIS ID
TVIS10007750
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2445
Orient
-
Integrated sequence
TGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCT| |CAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTT
Host Sequence
Chromosome
chr9
Cytoband
q34.11
Reference genome
GRCh37/hg19
Start
132317621/129555342 (Hg38)
End
132317621/129555342 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7a-1/Upstream/1162628; hsa-mir-12126/Downstream/314263;
Nearest TSS
ENST00000422679/Upstream/72804; ENST00000443993/Downstream/20067;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/4729, chr9-CpG: 68/Downstream/13349
Nearby gene
LINC00963(-41656) ; C9orf50(+56883) ;
Upstream sequence
gaaaagttgcaaagatagttcaaagaattcccatatatctttcacccaacttcctctaatgttaacgtcttacataaccagactgcctttgttaaaacta
Downstream sequence
atctcaaaaaaaaaaaGGAGGATGTTTGGTTCTTGTTTGCAAAAGACCATTCACTGCAGGGACAGGGACAGGGGCTTGGAGCCTGAGCCCCCCCTCAACC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate