Basic Information
VIS ID
TVIS10007752
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
236
Orient
+
Integrated sequence
TTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCAC| |AATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCAC
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
73957846/73492163 (Hg38)
End
73957846/73492163 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1L
Nearest miRNA
hsa-mir-101-1/Upstream/2424447; hsa-mir-11399/Downstream/3567980;
Nearest TSS
ENST00000473358/Upstream/184947; ENST00000424953/Downstream/143053;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1208110, chr1-CpG: 24/Downstream/705979
Nearby gene
NEGR1(-1209569) ; LRRIQ3(+533856) ;
Upstream sequence
cacggcttcccttggctaggaaagggaaatcccctgaccacttgtgcttcccaggtgaggcgatgccccaccctgcttcggctcaccctccatgggctgc
Downstream sequence
acccactgtccaaccagtcccaatgagaagaaccaggtacctcagttggaaaagcagaaatcacccgtcttctgcgtctatcatgctgggagctgcacac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate