Basic Information
VIS ID
TVIS10007758
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1079
Orient
+
Integrated sequence
TTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAA| |TCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGTGCC
Host Sequence
Chromosome
chr17
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
20606088/20702775 (Hg38)
End
20606088/20702775 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1180/Upstream/1358201; hsa-mir-10226/Downstream/6591135;
Nearest TSS
ENST00000595228/Upstream/69541; ENST00000578585/Downstream/85296;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/113393, chr17-CpG: 43/Downstream/81481
Nearby gene
CDRT15L2(-121864) ; CCDC144NL(+160620) ;
Upstream sequence
ttctggttttacaagatgaaaagagttttgtggatggatggtagtgataattgtataacagcatgaatgttcttaatacctctgaactgtatacctaaaa
Downstream sequence
ctggttaatatggtacattttatattatgtgtgttttaccacaattaatttttttttttaaatggggtctaactctgtcatccaggccagagtgtagtgg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate