Basic Information
VIS ID
TVIS10007762
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
494
Orient
+
Integrated sequence
TTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATC| |CTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAAT
Host Sequence
Chromosome
chr6
Cytoband
q12
Reference genome
GRCh37/hg19
Start
69073237/68363345 (Hg38)
End
69073237/68363345 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/10973133; hsa-mir-10524/Downstream/3013615;
Nearest TSS
ENST00000381078/Upstream/33446; ENST00000604969/Downstream/270979;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/2268407, chr6-CpG: 37/Downstream/271495
Nearby gene
ADGRB3(+272395) ;
Upstream sequence
ATTGAACTGTACTTGCTATAGTTTCAATGTAAGTAAAAACCCAGCAGTGATTTTTACTTTAGAAAAATGGGTCAGTGGTTTTATGCAAGGAGTAATGTTT
Downstream sequence
ggtcaggagatggagaccatcctggctaacatggtgaaaccccgtctctactaaaaatacaaaaaaattagccgggcgtggtggcgggcgcctgtagtcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate