VISDB Viral Integration Site DataBase

VIS ID

TVIS10007763

Fusion event

HBV-PRDM16 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|Polymerase|

Start

2372

Orient

-

Integrated sequence

TGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAG| |AAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAA

Chromosome

chr1

Cytoband

p36.32

Reference genome

Start

End

3306597/3390033 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-133b ; hsa-mir-133a-3p ; hsa-mir-96-5p ; hsa-mir-615-3p ; hsa-mir-346 ; hsa-mir-221-3p ; hsa-mir-101-3p

Nearest miRNA

hsa-mir-12136/Upstream/261998; hsa-mir-101-1/Downstream/170662;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/31313, chr1-CpG: 20/Downstream/472

Nearest cancer related gene

PRDM16(OG, No orient, 0)

Upstream sequence

CTTTTCTGGGGGTGCGCCCCCCCCCCCCCCCCACCCTCTGGCTCCTACTTTCCCTTTTGGAAAATTCAAGACACTCAGATCACCCCTGGGTGGTTCTTTC

Downstream sequence

TCCTGTAATTATGAACAAATGAGCTGGTTTGAAATGTTTCAGGAGACACAGACAGGGACAGTTCCTGAATTTGTTTTAACGTGAAGAAAGAAAACAAGAG