Basic Information
VIS ID
TVIS10007764
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1291
Orient
-
Integrated sequence
ACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGC| |TTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGT
Host Sequence
Chromosome
chr10
Cytoband
p15.3
Reference genome
GRCh37/hg19
Start
122330/76390 (Hg38)
End
122330/76390 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-107/Downstream/565299;
Nearest TSS
ENST00000562162/Upstream/2227; ENST00000439456/Downstream/58075;
Nearest CpG islands
chr10-CpG: 54/Target, None/Upstream, None/Downstream
Nearby gene
TUBB8(-27152) ; ZMYND11(+58075) ;
Nearest cancer related gene
ZMYND11(TSG, +58075) ;
Upstream sequence
CCCAGAAACAAAATCGCATCGGTAACCGGCATCTTGTCCTGTGCTGGGGGTGAGCCGCCCAAGCCTCCATGAAGGGACGCTCGTACAAAGTGAAGTCTGG
Downstream sequence
GTACAAATGGCCAGACGGGAAACGCGCCGCGCTCGCTCCGCTGCACTCACAGCGGCGGCAGGAAGCCTTTTTCTCACTTTCTCCCCGGCGGCCCCAGGTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate