Basic Information
VIS ID
TVIS10007767
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1993
Orient
+
Integrated sequence
CTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTC| |TAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGA
Host Sequence
Chromosome
chr4
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
163854379/162933227 (Hg38)
End
163854379/162933227 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/3804333; hsa-mir-1305/Downstream/160347;
Nearest TSS
ENST00000502981/Upstream/192559; ENST00000504628/Downstream/175558;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/3829244, chr4-CpG: 71/Downstream/233082
Nearby gene
FSTL5(-769193) ; NAF1(+193481) ;
Upstream sequence
cattccattccattccattccattccattccattccattccattccactcgggttgattccattccattccattccattccattccattccattccattc
Downstream sequence
AGTTTATGTACATATTAACAAAACAAACAATATCATACATagtcacccattgcttaatggtggagatacattcagagaaatgcatcttcaggtgatttta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate