VISDB Viral Integration Site DataBase

VIS ID

TVIS10007768

Fusion event

HBV-MAP3K7 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|

Start

1897

Orient

+

Integrated sequence

GGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTT| |GGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGA

Chromosome

chr6

Cytoband

q15

Reference genome

Start

End

91249008/90539289 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-10a-5p ; hsa-mir-34a-5p ; hsa-mir-103a-3p ; hsa-mir-1226-5p ; hsa-mir-16-5p ; hsa-mir-143-3p ; hsa-mir-4635 ; hsa-mir-4709-3p ; hsa-mir-3914 ; hsa-mir-548au-3p ; hsa-mir-107 ; hsa-mir-545-3p ; hsa-mir-1295b-3p ; hsa-mir-449c-5p ; hsa-mir-34b-5p ; hsa-mir-2682-5p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-599 ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-5589-3p ; hsa-mir-875-5p ; hsa-mir-646 ; hsa-mir-503-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-3671 ; hsa-mir-153-5p ; hsa-mir-1250-3p ; hsa-mir-892b

Nearest miRNA

hsa-mir-10398/Upstream/226456; hsa-mir-1202/Downstream/982371;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/242064, chr6-CpG: 64/Downstream/47350

Nearest cancer related gene

MAP3K7(OG, No orient, 0)

Upstream sequence

CTTGCTATAGTTTCAATGTAAGTAAAAACCCAGCAGTGATTTTTACTTTAGAAAAATGGGTCAGTGGTTTTATGCAAGGAGTAATGTTTTAATACAAATA

Downstream sequence

agactatacaatatggcagaaaggccacctaaatattcattataaagttagattaacttccctatttaatatgccacaaatagagaattttattgaaagt