Basic Information
VIS ID
TVIS10007770
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3174
Orient
+
Integrated sequence
ACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCA| |TGCAGTGG
Host Sequence
Chromosome
chr7
Cytoband
q31.33
Reference genome
GRCh37/hg19
Start
123817949/124177895 (Hg38)
End
123817949/124177895 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10525/Upstream/7157576; hsa-mir-10399/Downstream/2880193;
Nearest TSS
ENST00000635602/Upstream/144872; ENST00000497598/Downstream/109649;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/144258, chr7-CpG: 19/Downstream/586225
Nearby gene
TMEM229A(-144426) ; GPR37(+568165) ;
Upstream sequence
aacctgccaaaaaccagcaaggtgaggaaaactacctctggtcttcctcattgctcattattcgctaattacaatgcattctcatgctaaacgacactcc
Downstream sequence
atataatatgataatagaaaatataaaataaaatgaatgaaatttgttcaactataagtaatcacagtacatataaaCTTCATTACAAGAAAGAAACTCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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