VISDB Viral Integration Site DataBase

VIS ID

TVIS10007794

Fusion event

HBV-PHF21A integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

409

Orient

+

Integrated sequence

AATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCT| |TCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCAC

Chromosome

chr11

Cytoband

p11.2

Reference genome

Start

End

46132675/46111124 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-221-3p ; hsa-mir-548c-3p ; hsa-mir-7855-5p ; hsa-mir-216a-5p ; hsa-mir-129-5p ; hsa-mir-1909-3p ; hsa-mir-4270 ; hsa-mir-4441 ; hsa-mir-4468 ; hsa-mir-6081 ; hsa-mir-6132 ; hsa-mir-6722-3p ; hsa-mir-6754-5p ; hsa-mir-6836-5p ; hsa-mir-759

Nearest miRNA

hsa-mir-129-2/Upstream/419348; hsa-let-7a-2/Downstream/265278;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/187902, chr11-CpG: 65/Downstream/8704

Upstream sequence

tccacccgcctcagcctaccaaagagctgggattacaggcgtgagccaccgcgcctggccATATTAACAAATTTTAAATCACAACTATGTGGGGGGGGAG

Downstream sequence

GCTAGTATTATTACAGCAGATTGGTTTGCTATATAAACAAGTACTTTAAAAAATATTTCTTGggccaggcgtggtggctcacgcctgtaatcccagcact