Basic Information
VIS ID
TVIS10007828
Fusion event
HBV-LOC105378486 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1821
Orient
-
Integrated sequence
TGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAA| |CTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATA
Host Sequence
Chromosome
chr10
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
113551434/111791676 (Hg38)
End
113551434/111791676 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
LOC105378486
Nearest miRNA
hsa-mir-107/Upstream/802663; hsa-mir-202/Downstream/507936;
Nearest TSS
ENST00000439456/Upstream/439573; ENST00000643850/Downstream/392034;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/712131, chr10-CpG: 35/Downstream/391849
Nearby gene
ADRA2A(-710772) ; GPAM(+358188) ;
Upstream sequence
tacggttctagctgcatcctgtagcttttgatatgttgtgctgccattttggtactgtatcttggacatttttaatattatcttatgagtgactggatct
Downstream sequence
tttcaaaattctatcgagaattttgatatttttgttttaactaggcaattcacccagttaggttcaagctgcaacttataattagcctcctatgaattct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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