Basic Information
VIS ID
TVIS10007829
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1844
Orient
+
Integrated sequence
GGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCAT| |CTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAG
Host Sequence
Chromosome
chr10
Cytoband
p14
Reference genome
GRCh37/hg19
Start
9462030/9420067 (Hg38)
End
9462030/9420067 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-3155a/Upstream/3267790; hsa-mir-107/Downstream/2710693;
Nearest TSS
ENST00000439456/Upstream/144234; ENST00000429539/Downstream/339170;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/11821, chr10-CpG: 30/Downstream/846128
Nearby gene
GATA3(-1344866) ; SFTA1P(+1364372) ;
Upstream sequence
gatcttttccatctgacatctgcctgaagaattttcctttaacatctcctgaagtcaaaatctgctgccaatgaattctttcagtttgcaaatattttct
Downstream sequence
cccaggggatggattgtcttttcattttcttagcagtaaattgtgaggatgatacatgtttaatttggaataagtttaatttaacacatttttacatttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate