VISDB Viral Integration Site DataBase

VIS ID

TVIS10007831

Fusion event

HBV-IGF2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1761

Orient

-

Integrated sequence

GGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTT| |AAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTA

Chromosome

chr11

Cytoband

p15.5

Reference genome

Start

End

2149801/2128571 (Hg38)

Orient

+

Location type

downstream

Target gene

miRNAs that regulate target gene

hsa-let-7a-5p ; hsa-mir-125b-5p ; hsa-mir-150-5p ; hsa-mir-615-5p ; hsa-mir-877-5p ; hsa-mir-93-5p ; hsa-mir-100-5p ; hsa-mir-9-3p ; hsa-mir-6881-5p ; hsa-mir-6738-5p ; hsa-mir-5194 ; hsa-mir-1914-3p ; hsa-mir-339-3p ; hsa-mir-4521 ; hsa-mir-6891-5p ; hsa-mir-4779 ; hsa-mir-3173-3p ; hsa-mir-4428 ; hsa-mir-4429 ; hsa-mir-320d ; hsa-mir-320c ; hsa-mir-320b ; hsa-mir-320a ; hsa-mir-5003-3p ; hsa-mir-4662a-5p ; hsa-mir-429 ; hsa-mir-200c-3p ; hsa-mir-8084 ; hsa-mir-200b-3p ; hsa-mir-4728-3p ; hsa-mir-3622a-3p ; hsa-mir-6763-3p ; hsa-mir-6802-3p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-6862-3p ; hsa-mir-6784-3p ; hsa-mir-6078 ; hsa-mir-1915-5p ; hsa-mir-4485-5p ; hsa-mir-3162-3p ; hsa-mir-5587-3p ; hsa-mir-4707-5p ; hsa-mir-1224-3p ; hsa-mir-3200-3p ; hsa-mir-663b

Nearest miRNA

hsa-mir-210/Upstream/131740; hsa-let-7a-2/Downstream/5563;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/115810, chr11-CpG: 23/Downstream/4232

Nearest cancer related gene

IGF2(OG, No orient, 0)

Upstream sequence

CTGGAAAGTTCCTGGAGGGGGATGGAGAGAAGAGGCTGGGCCAGGCTCCCAGCAGCCCAGCCTACCCCTCCTCCCATGCTCAGGGACCCTTGAAAGCTAG

Downstream sequence

AGGCCAGCACCCTTGGGACAGGTGGGTACAGGCTGAGCCCTGGCAGGAGGCAGTGGTACTAATGACATCTGGGCAGCCTCAACCTTGGAAGGGGGCTGAG