Basic Information
VIS ID
TVIS10007834
Fusion event
HBV-LOC105376755 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1033
Orient
-
Integrated sequence
AAATCAAAGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTAC| |ACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAA
Host Sequence
Chromosome
chr2
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
195833815/194969091 (Hg38)
End
195833815/194969091 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105376755
Nearest miRNA
hsa-mir-10b/Upstream/5835980; hsa-mir-1244-1/Downstream/11814143;
Nearest TSS
ENST00000437798/Upstream/238496; ENST00000413290/Downstream/57279;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/2773005, chr2-CpG: 150/Downstream/687740
Nearby gene
SLC39A10(+687717) ;
Upstream sequence
AAAGCAGCTGTGCTGATTAAATTCATTGACACAATGTGTTCTTATGTAACAGACCTGTTCTAAAAAGTATCGCCTGATGCCAAAACAATATCAGCTCCCT
Downstream sequence
CTCTCCACCTCCTTTGAATGACAGCAACCTTTCTGAGATACCTACATGGTTAGGACCCAATACACCTGGGTAAGTATCCCCAATACTGAACACGTAGATT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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