Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007835
Fusion event
HBV-KCNMB2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|precore/core protein|
Start
1818
Orient
-
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr3
Cytoband
q26.32
Reference genome
End
178464574/178746786 (Hg38)
Orient
-
Location type
Intronic
Target gene
Nearest miRNA
hsa-let-7g/Upstream/2231635; hsa-mir-1224/Downstream/5140014;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1548720, chr3-CpG: 63/Downstream/324731
Upstream sequence
TGGAAGAAGTATATTTCTCAGGTGAGATACTTTTACTTCCTCTTCTACTGTGTAATTTATTAATACATGGACTTCTGTTATGTAGTTGCTTACTTTTGTG
Downstream sequence
gctaaagcatgaaaagagtcacctttgctccagttcccaacaagttcctcatctccatctgagaccacctcagcctggaccttattgttcatatcactat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.