Basic Information
VIS ID
TVIS10007837
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1872
Orient
+
Integrated sequence
TACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCC| |TCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCT
Host Sequence
Chromosome
chr3
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
35544657/35503165 (Hg38)
End
35544657/35503165 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12127/Upstream/2996776; hsa-let-7g/Downstream/241311;
Nearest TSS
ENST00000440867/Upstream/959285; ENST00000421492/Downstream/135780;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1703986, chr3-CpG: 86/Downstream/135852
Nearby gene
PDCD6IP(-1633458) ; ARPP21(+136009) ;
Upstream sequence
TTTGCATTCTTGAATGTTTTTAGACAAAATTTTAGAAAATCCTAGCAAAACATCTTAATAGTCTAGAGGAAAAAGTGCTATGTCTTACTGATTTTAAGAA
Downstream sequence
cattgatgacaactttttatctgacttttcttttacttccttgttctattcactcattcctggttcttgaggtcacttcccaaattaacctccagtactc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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