Basic Information
VIS ID
TVIS10007839
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2628
Orient
+
Integrated sequence
GGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATT| |GCAATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCAT
Host Sequence
Chromosome
chr5
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
123057294/123721600 (Hg38)
End
123057294/123721600 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/4566884; hsa-mir-103a-1/Downstream/5376088;
Nearest TSS
ENST00000502646/Upstream/133175; ENST00000510004/Downstream/673439;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/85286, chr5-CpG: 48/Downstream/930105
Nearby gene
CSNK1G3(-104556) ; ZNF608(+915316) ;
Upstream sequence
taaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaac
Downstream sequence
TTCCTCATTGTAGATTATATTTTCCAGGTGAATAGAATTGAAGCTCTCAGATGATATAGCATCCCTGTGAGAAATTATGTAGCTAGTATAGAGACCTATT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate