Basic Information
VIS ID
TVIS10007843
Fusion event
HBV-MIR548T integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1799
Orient
-
Integrated sequence
GAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGG| |TCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGG
Host Sequence
Chromosome
chr7
Cytoband
q35
Reference genome
GRCh37/hg19
Start
147854431/148157339 (Hg38)
End
147854431/148157339 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA7I
Target gene
MIR548T
Nearest miRNA
hsa-mir-10399/Upstream/779218; hsa-mir-153-2/Downstream/3081082;
Nearest TSS
ENST00000635602/Upstream/23655; ENST00000636988/Downstream/15045;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/2040347, chr7-CpG: 33/Downstream/182063
Upstream sequence
caagcaaatgaacatatcacctcacatagttataattttgtgtgttgagaacacttaagatctaccctcttagcaaatttcaaggatacaatagtattaa
Downstream sequence
ATAAATATTTGCTGAGCAAACATCTGGATGAATAAATAAGTGATTGTGATTTTTCTGGGTTAATATCCATATTCAAAATTAGATCATCTCCTTTCCAAAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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