Basic Information
VIS ID
TVIS10007845
Fusion event
HBV-FRG1JP integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1824
Orient
-
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG
Host Sequence
Chromosome
chr9
Cytoband
q13
Reference genome
GRCh37/hg19
Start
68439234/63843500 (Hg38)
End
68439234/63843500 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA9F
Target gene
FRG1JP
Nearest miRNA
hsa-mir-101-2/Upstream/22609665; hsa-let-7a-1/Downstream/6966475;
Nearest TSS
ENST00000422679/Upstream/29341; ENST00000615302/Downstream/525894;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/25322, chr9-CpG: 71/Downstream/15668
Upstream sequence
CTACCTTAATTTTTCAAGGTGATTAAGCTGATTAAGTAAGAACACTGTGATTCTTCATTCATTCGTCTTCACTTAACCAGACAGAAAGGTCTTTCTTACA
Downstream sequence
GACCCCAGCCATCTATTCATGCCTGCTTTCCAGAGGCAATGCCTATCATAATGCTTCTTAAAAATGCCTCTACAGGAAGACTTTCTAGCATAGTAAtttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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