Basic Information
VIS ID
TVIS10007846
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2085
Orient
+
Integrated sequence
AGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGC| |TGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCC
Host Sequence
Chromosome
chrX
Cytoband
p11.22
Reference genome
GRCh37/hg19
Start
52061946/52318802 (Hg38)
End
52061946/52318802 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1587/Upstream/2304119; hsa-let-7f-2/Downstream/17755;
Nearest TSS
ENST00000429181/Upstream/118962; ENST00000286049/Downstream/50228;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/56473, chrX-CpG: 65/Downstream/578057
Nearby gene
MAGED4B(-126582) ; XAGE2(+50132) ;
Upstream sequence
AGGGCTCATCCCCTGTACATCAGCTAGCAGGTTGGCAGCAAGACCAATCCCAGGCTGTGGCTGCTGGAGGAACAGGAGAAATCATGGGTTTCTGCCTTGG
Downstream sequence
tctgattttgtatgtctgaaaaagactttattttgccactgttcttaaaagttatttgtactgtgtatagaattctaggctgacagggatttttttttca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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