Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007854
Fusion event
HBV-FBXO15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
2306
Orient
-
Integrated sequence
GGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACC| |AAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCT
Host Sequence
Chromosome
chr18
Cytoband
q22.3
Reference genome
Start
End
71814075/74146840 (Hg38)
Orient
-
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-1-2/Upstream/1293458;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/1277204, chr18-CpG: 97/Downstream/480
Upstream sequence
ACCTAGAGAGGACACAGGACATAGTTCTGGAGATTCAGGGGGAAAAAACAAGTAGTTCAACTAGTATGTAATAGACTCCCTTTGTGTGCTTAAACATAGA
Downstream sequence
CCATTGGTTTATTAGAAGGCAAAATATGCATGACTTTCCCTATTTATAAATCAAGGAGTCTTACAAGCAGAAAGATAATCCTCAAGAATGTAAACCATTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.