CCDC146 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007859
Fusion event
HBV-CCDC146 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
41
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGT| |GAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGG
Host Sequence
Chromosome
chr7
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
76835294/77205977 (Hg38)
End
76835294/77205977 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
CCDC146
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10525/Upstream/1290708; hsa-mir-10399/Downstream/14998038;
Nearest TSS
ENST00000635602/Upstream/6129; ENST00000461882/Downstream/36369;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/83900, chr7-CpG: 111/Downstream/209546
Upstream sequence
NNNNNNNNNNNNNNNNNNNNctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccct
Downstream sequence
tacagtatgagatctaaaagaaggcagaaagttgccttctttgacttcagctgggtatatatgtatttggcaaatcaacatatttaccacgctacgcatg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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