MYO3B _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007872
Fusion event
HBV-MYO3B integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2329
Orient
+
Integrated sequence
TTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACAC| |TTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATC
Host Sequence
Chromosome
chr2
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
171274983/170418473 (Hg38)
End
171274983/170418473 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2G
Target gene
MYO3B
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1-3p
Nearest miRNA
hsa-mir-128-1/Upstream/1835455; hsa-mir-10b/Downstream/4749160;
Nearest TSS
ENST00000437798/Upstream/9909; ENST00000487037/Downstream/276901;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/590354, chr2-CpG: 44/Downstream/293339
Upstream sequence
TTATTGTATTAATATCATCGCTACTAAATTTTCTCTTTGCAAAACTAGAATTTTAAGCTGGAATCTGGAGAAGTGTGATTTCCCTGGAAAAGAGTTTGTA
Downstream sequence
GACCTCTTTGTTTGTGAAAAGTGCATCCCTAGGTCTTCATAAAAGCTCTAGCACCTAACTGAAAAATACAGGAGCTCTTAATAACAGCCAATGTTTACAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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