Basic Information
VIS ID
TVIS10007882
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1825
Orient
-
Integrated sequence
TAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTT| |TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGA
Host Sequence
Chromosome
chr4
Cytoband
q34.3
Reference genome
GRCh37/hg19
Start
180746440/179825287 (Hg38)
End
180746440/179825287 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/5401423; hsa-mir-1305/Downstream/2344006;
Nearest TSS
ENST00000502981/Upstream/359982; ENST00000512480/Downstream/933751;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/2382733, chr4-CpG: 160/Downstream/232598
Nearby gene
LINC01098(-1834536) ; LINC00290(+1238803) ;
Upstream sequence
AAGAAAAAAAGGCAATTTATACAAATTAATTTTCAAGCTATTTGTGTTTGCTTAGTGTAGAAGACAATTGTTTTTCTAATTAATATAGTTACTATTTCTT
Downstream sequence
CCTCTGTATTTTGTAAAACGTGGCTATAACATTTACAGGAGTGAGACACACCATCATATTTCATGCAAGAGAGCAAAGCTCCAAATACCAATGATGTGTA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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