Basic Information
VIS ID
TVIS10007886
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
662
Orient
-
Integrated sequence
CCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCG| |TTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGG
Host Sequence
Chromosome
chr9
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
128759021/125996742 (Hg38)
End
128759021/125996742 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7a-1/Upstream/1302944; hsa-mir-12126/Downstream/1693945;
Nearest TSS
ENST00000422679/Upstream/131471; ENST00000441473/Downstream/60838;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/106725, chr9-CpG: 16/Downstream/18736
Nearby gene
PBX3(-29366) ; MVB12B(+330102) ;
Upstream sequence
cctgggctccagcaaacctcccgcatcagcctccaagtagctagggctacaggcatgcatcagcaagcccagcttaaaaaaaaaaaatgctgtagagatg
Downstream sequence
cctgggaccacaggcacgcaccaccacacccagctaattgtttgtagagttggggtctccctgtgttgcccaggctggtctcagactcctgggctcaagt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate