Basic Information
VIS ID
TVIS10007887
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1845
Orient
+
Integrated sequence
GGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATC| |TCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGT
Host Sequence
Chromosome
chr1
Cytoband
p12
Reference genome
GRCh37/hg19
Start
118084364/117541742 (Hg38)
End
118084364/117541742 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/447014; hsa-mir-1182/Downstream/28308845;
Nearest TSS
ENST00000473358/Upstream/38881; ENST00000369448/Downstream/63943;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/173919, chr1-CpG: 135/Downstream/63594
Nearby gene
MAN1A2(-16044) ; TENT5C(+64240) ;
Upstream sequence
GCAGCCTCATTCACCCAGAGCCCATGGCTTATTGTTCACGGGCCAGCAAAGTATCTTGAAAAGTGACAGCAGGGAGCAGAATACTCCTTGGCCTCTCCAG
Downstream sequence
GAGCCAGTGGATGCCGGAAGAGACCTTGGTTGATACGGTTCCTGATCTCCCAGCAACACTGGAAGAGCAAAGGCTGCAGAAAGCACAGCCACAGCCACTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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