VISDB Viral Integration Site DataBase

VIS ID

TVIS10007888

Fusion event

HBV-ARHGEF2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

603

Orient

+

Integrated sequence

CAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGT| |ATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGT

Chromosome

chr1

Cytoband

q22

Reference genome

Start

End

155956155/155986364 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-96-5p ; hsa-mir-877-3p ; hsa-mir-744-5p ; hsa-mir-423-3p ; hsa-mir-320a ; hsa-mir-4728-5p ; hsa-mir-328-3p ; hsa-mir-6734-5p ; hsa-mir-1226-5p ; hsa-mir-6834-5p ; hsa-mir-3175 ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-6851-3p ; hsa-mir-6775-3p ; hsa-mir-1291 ; hsa-mir-6799-3p ; hsa-mir-3173-5p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-6738-5p ; hsa-mir-5194 ; hsa-mir-1914-3p ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-7845-5p ; hsa-mir-942-3p ; hsa-mir-4475 ; hsa-mir-194-3p

Nearest miRNA

hsa-mir-101-1/Upstream/35028; hsa-mir-1182/Downstream/433977;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/7665, chr1-CpG: 33/Downstream/34234

Nearby gene

ARHGEF2(-7819) ; SSR2(+22684) ;

Nearest cancer related gene

ARHGEF2(OG, No orient, 0)

Upstream sequence

gtggcgggatctcggctcactgcaagctccgcctcccgggttcacgccattctcctgcctcagcctcccaagtagctgggactacaggcgcccgccacta

Downstream sequence

cgcccggctaattttttgtatttttagtagagacggggtttcaccgtttttagccgggatggtctcgatctcctgacctcgtgatccgcccgcctcagcc