Basic Information
VIS ID
TVIS10007889
Fusion event
HBV-COP1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
2202
Orient
+
Integrated sequence
TCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTC| |TTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGAC
Host Sequence
Chromosome
chr1
Cytoband
q25.2
Reference genome
End
176116444/176147308 (Hg38)
Orient
+
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-101-1/Upstream/178829; hsa-mir-1182/Downstream/882055;
Nearest cancer related gene
COP1(TSG, No orient, 0)
Upstream sequence
ACACGCAAATAGACTTACATGGAAGAAGAAAATATAACCACTCACTTCAATCTGTCTGCACTAAAACATATTTTCTAGACTAAAGCTTATTATAATTACA
Downstream sequence
AATCACTATAGTACCCAATTCCAATTATTGTGAAATTCAAGAAATTTAATCAAAGTAGTAGATAAACGTTTACAATTTGTTACCTAGCTCCTCAGAATTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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