Basic Information
VIS ID
TVIS10007893
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1348
Orient
-
Integrated sequence
TTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGT| |CCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAAT
Host Sequence
Chromosome
chr1
Cytoband
p36.12
Reference genome
GRCh37/hg19
Start
22442749/22116256 (Hg38)
End
22442749/22116256 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1A
Nearest miRNA
hsa-mir-12136/Upstream/1127824; hsa-mir-101-1/Downstream/149983;
Nearest TSS
ENST00000473358/Upstream/15643; ENST00000400239/Downstream/13595;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/62720, chr1-CpG: 35/Downstream/3771
Nearby gene
CDC42(-23313) ; WNT4(+1049) ;
Upstream sequence
aagaagtggcagtgctgggatccaaaccaggtctatctgatttcaaagcctgggacctttgcaTAGTGCTAGAAAATGGTTCAGCATGGTCACCTTGACT
Downstream sequence
TCTTGGTTTGGttttgttttgagacagggtcttgccctgttgcctaggctggagtgcagtgatgcagtctcagttcactgcaacttctgtccccaaggct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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