VISDB Viral Integration Site DataBase

VIS ID

TVIS10007898

Fusion event

HBV-PLPP3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

2713

Orient

+

Integrated sequence

TGAGAAAAGAAGATTGCAATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAA| |CATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTT

Chromosome

chr1

Cytoband

p32.2

Reference genome

Start

End

57032199/56566526 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-7-5p ; hsa-mir-98-5p ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-620 ; hsa-mir-1270 ; hsa-mir-4531 ; hsa-mir-6883-3p ; hsa-mir-5192 ; hsa-mir-5186 ; hsa-mir-3120-5p ; hsa-mir-4502 ; hsa-mir-3162-3p ; hsa-mir-181b-5p ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181a-5p ; hsa-mir-4262 ; hsa-mir-185-5p ; hsa-mir-4306 ; hsa-mir-4644 ; hsa-mir-451b ; hsa-mir-2278 ; hsa-mir-4511 ; hsa-mir-15a-5p ; hsa-mir-424-5p ; hsa-mir-15b-5p ; hsa-mir-16-5p ; hsa-mir-497-5p ; hsa-mir-6838-5p ; hsa-mir-195-5p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6845-3p ; hsa-mir-138-2-3p ; hsa-mir-6809-3p ; hsa-mir-6827-3p ; hsa-mir-340-3p ; hsa-mir-4279 ; hsa-mir-365b-5p ; hsa-mir-365a-5p ; hsa-mir-8052 ; hsa-mir-3199 ; hsa-mir-6789-3p ; hsa-mir-6778-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-150-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-6814-5p ; hsa-mir-5697 ; hsa-mir-1295b-3p ; hsa-mir-625-3p ; hsa-mir-562 ; hsa-mir-4532 ; hsa-mir-1247-3p ; hsa-mir-6887-3p ; hsa-mir-122-3p ; hsa-mir-184

Nearest miRNA

hsa-mir-12136/Upstream/1340803; hsa-mir-101-1/Downstream/3166701;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/88529, chr1-CpG: 95/Downstream/11903

Upstream sequence

atagtaacaagtactttataggctcattgggaggattaaataagagaatgtatacacgctgcttaacctggtgagaggtacctagctagcactcaataaa

Downstream sequence

tgtCAGCAATCGTCATTATttagtcaagcttgagtccaaattccagccccgatacatatcagctgtaagaacttgggcaaatcatttaccctctctgagc