Basic Information
VIS ID
TVIS10007900
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2074
Orient
-
Integrated sequence
CCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAG| |CAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACAC
Host Sequence
Chromosome
chr10
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
107361247/105601489 (Hg38)
End
107361247/105601489 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Nearest miRNA
hsa-mir-107/Upstream/1333084; hsa-mir-202/Downstream/5296601;
Nearest TSS
ENST00000439456/Upstream/442561; ENST00000424701/Downstream/217708;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/958435, chr10-CpG: 100/Downstream/1562533
Nearby gene
SORCS3(-336254) ; SORCS1(+972174) ;
Upstream sequence
gggttattactacagagaaagccaaatcccatcgaggtgaacctgatatttggtaccttttaaccttagatgtcttttctcaggaacaaacaataccaac
Downstream sequence
aaataatatcagctaagaaactgaaaaacttagcagagataacagcagtttTGGATCTCTCTCTCTGTCTCTCCACATGTATACATGTACCATCTTCCCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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