Basic Information
VIS ID
TVIS10007901
Fusion event
HBV-LOC107984191 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2358
Orient
+
Integrated sequence
GGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGA| |GGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATT
Host Sequence
Chromosome
chr10
Cytoband
p15.3
Reference genome
GRCh37/hg19
Start
312740/266800 (Hg38)
End
312740/266800 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC107984191
Nearest miRNA
hsa-mir-107/Downstream/374889;
Nearest TSS
ENST00000439456/Upstream/22329; ENST00000425723/Downstream/62726;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/130288, chr10-CpG: 32/Downstream/33764
Nearby gene
ZMYND11(-12163) ; DIP2C(+7390) ;
Upstream sequence
aagtatatatataaaaaaaaTTCTTTTCTCTcatttctatggacaggaataatttgtattatcataagttctctacaatgtatagagctgtaaagtagct
Downstream sequence
caaagacaataaaatgcagagataacctggatggctgagctAGTCAGGACATCCAAAAATATATATATTTTTGCCCATGTAAAAATCTTTCAAAGTATTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate