Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007903
Fusion event
HBV-OGDHL integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|
Start
1783
Orient
-
Integrated sequence
GTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGC| |TGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTG
Host Sequence
Chromosome
chr10
Cytoband
q11.23
Reference genome
Start
End
50971096/49763050 (Hg38)
Orient
+
Location type
upstream
Fragile sites / regions
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-1265/Upstream/777463; hsa-mir-107/Downstream/1536523;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/491, chr10-CpG: 85/Downstream/5251
Upstream sequence
ggttttctgttGTATTTTTTTCAGCTTTCTGTTGGGTTTTGTTCTCATTTAAATGCAGGGATTTCTTGTATAGGAACATAACATACCTGtggttcaagtt
Downstream sequence
gccatcaaatctctcctggattatcgcagcagcctcctaactggcttctctgcttctacacttacactcttgaattttaatctcaaaactacagtatgca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.