VISDB Viral Integration Site DataBase

VIS ID

TVIS10007911

Fusion event

HBV-METTL7A integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

2751

Orient

+

Integrated sequence

TTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTT| |ACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCAT

Chromosome

chr12

Cytoband

q13.12

Reference genome

Start

End

51323772/50929989 (Hg38)

Orient

+

Location type

Exonic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-146a-5p ; hsa-mir-124-3p ; hsa-mir-320a ; hsa-mir-580-3p ; hsa-mir-499a-5p ; hsa-mir-208b-3p ; hsa-mir-208a-3p ; hsa-mir-7153-5p ; hsa-mir-146b-5p ; hsa-mir-589-5p ; hsa-mir-200b-5p ; hsa-mir-200a-5p ; hsa-mir-8087 ; hsa-mir-4432 ; hsa-mir-548s ; hsa-mir-3606-5p ; hsa-mir-6073 ; hsa-mir-3926 ; hsa-mir-3190-5p ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-339-5p ; hsa-mir-6849-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-6732-3p ; hsa-mir-6726-3p ; hsa-mir-6818-3p ; hsa-mir-4684-5p ; hsa-mir-6867-3p ; hsa-mir-3682-5p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-138-1-3p ; hsa-mir-1288-5p ; hsa-mir-1910-3p ; hsa-mir-3622a-3p ; hsa-mir-3622b-3p ; hsa-mir-3672 ; hsa-mir-4514 ; hsa-mir-4692 ; hsa-mir-4786-5p ; hsa-mir-544b ; hsa-mir-6511a-5p ; hsa-mir-6765-3p ; hsa-mir-6864-3p ; hsa-mir-7162-3p ; hsa-mir-769-5p ; hsa-mir-873-5p

Nearest miRNA

hsa-mir-1244-3/Upstream/695777; hsa-let-7i/Downstream/1968900;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/86848, chr12-CpG: 73/Downstream/95868

Upstream sequence

TTTTTTTTTTTCTTTCTTTCTCAGGGAGGGGCTTTCTATTTCATGGAGCATGTGGCAGCTGAGTGTTCGACTTGGAATTACTTCTGGCAACAAGTCCTGG

Downstream sequence

ATCCTGCCTGGCACCTTCTGTTTGATGGGTGCAACCTGACCAGAGAGAGCTGGAAGGCCCTGGAGCGGGCCAGCTTCTCTAAGCTGAAGCTGCAGCACAT