Basic Information
VIS ID
TVIS10007912
Fusion event
HBV-LOC101928617 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1727
Orient
-
Integrated sequence
GCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTA| |AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT
Host Sequence
Chromosome
chr12
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
92556356/92162580 (Hg38)
End
92556356/92162580 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12B
Target gene
LOC101928617
Nearest miRNA
hsa-let-7i/Upstream/5417431; hsa-mir-1178/Downstream/2399209;
Nearest TSS
ENST00000382841/Upstream/16133; ENST00000508671/Downstream/201252;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/16023, chr12-CpG: 133/Downstream/765986
Nearby gene
BTG1(-16683) ; CLLU1OS(+257514) ;
Upstream sequence
ttagcagtaggattaccaaaccaaatgttttacttttagttatttgagaaatctccatgctgttttccataaaggttacacaaatttacattcccactaa
Downstream sequence
cagtgtataagcattccctttccgccatgtccttgccaacatctgttgttttttgacttttcaataatagccattctgactggtgaaagatgatacctca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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