Basic Information
VIS ID
TVIS10007914
Fusion event
HBV-LHFPL6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
450
Orient
+
Integrated sequence
TCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTG| |GACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCT
Host Sequence
Chromosome
chr13
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
40061197/39487060 (Hg38)
End
40061197/39487060 (Hg38)
Orient
+
Location type
Intronic
Target gene
LHFPL6
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-let-7g-3p ; hsa-mir-493-5p ; hsa-let-7a-2-3p ; hsa-let-7c-3p ; hsa-mir-6867-5p ; hsa-mir-3613-5p ; hsa-mir-323a-3p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-3149 ; hsa-mir-3668 ; hsa-mir-376a-2-5p ; hsa-mir-3935 ; hsa-mir-568 ; hsa-mir-7852-3p ; hsa-mir-8068
Nearest miRNA
hsa-mir-2276/Upstream/15324556; hsa-mir-1267/Downstream/176974;
Nearest TSS
ENST00000623511/Upstream/433988; ENST00000630730/Downstream/116111;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/448267, chr13-CpG: 75/Downstream/115652
Upstream sequence
TGCTATCTTCTGAGGCAGCCACAGCTTGCACAAGGGTCAAAACTGAACTCAAAGAAATGTAAATTTACCCTTTCTATCCAAAGAAAGATGTATTTGACTC
Downstream sequence
ACTGATAAATGAAATGTGAGCTGTTTCTCACAAACTACACATATAATCTTAAAAATCTTTTGGAAACCATCCAACAGACAAAATCAGCTACTCTAGAAAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate