VISDB Viral Integration Site DataBase

VIS ID

TVIS10007919

Fusion event

HBV-PPP2R5C integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1760

Orient

-

Integrated sequence

AGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGT| |TAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCT

Chromosome

chr14

Cytoband

q32.31

Reference genome

Start

End

102255163/101788826 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-16-5p ; hsa-mir-30a-5p ; hsa-mir-31-3p ; hsa-mir-135b-5p ; hsa-mir-15a-5p ; hsa-mir-103a-3p ; hsa-mir-107 ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-1277-5p ; hsa-mir-3190-3p ; hsa-mir-3607-5p ; hsa-mir-3611 ; hsa-mir-4524a-5p ; hsa-mir-5011-5p ; hsa-mir-4524b-5p ; hsa-mir-6505-5p ; hsa-mir-6833-5p ; hsa-mir-6838-5p ; hsa-mir-7114-5p ; hsa-mir-29c-5p ; hsa-mir-4680-5p ; hsa-mir-134-3p ; hsa-mir-646 ; hsa-mir-503-5p ; hsa-mir-3664-5p ; hsa-mir-548ao-3p ; hsa-mir-193b-3p ; hsa-mir-193a-3p

Nearest miRNA

hsa-mir-1185-1/Upstream/228404; hsa-mir-12121/Downstream/750818;

Nearest TSS

Nearest CpG islands

None/Target, chr14-CpG: 35/Upstream/6884, chr14-CpG: 17/Downstream/102724

Nearest cancer related gene

PPP2R5C(TSG, No orient, 0)

Upstream sequence

AAAACATTAATGCCTCTGTATATATACTAAAATAATTTCACCTAGTTCAGAAAAATAATAAttgattggaattaaagttatatattaatttggtgaaaat

Downstream sequence

tgataccttttttccatctaggaagatggtatatatcccccatttttctgggtcttgttttctgacttataaaattttatggttttcttgtaaatctcta