IRF8 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007923
Fusion event
HBV-IRF8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2640
Orient
+
Integrated sequence
CTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTGCAATTGATTAT| |GCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACT
Host Sequence
Chromosome
chr16
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
85938380/85904774 (Hg38)
End
85938380/85904774 (Hg38)
Orient
+
Location type
Intronic
Target gene
IRF8
miRNAs that regulate target gene
hsa-mir-4686 ; hsa-mir-646
Nearest miRNA
hsa-mir-12128/Upstream/163074; hsa-mir-11401/Downstream/13573;
Nearest TSS
ENST00000527434/Upstream/1643; ENST00000569145/Downstream/4214;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/5438, chr16-CpG: 24/Downstream/43272
Nearest cancer related gene
IRF8(TSG, No orient, 0)
Upstream sequence
GCCCCCACACGTTCCAGATTCTTTCTGATCAAGGACCCCAGGTCAGGGAGCCTCAGCACCAAGAAGTTTTGTGATGCCACTGCCTGCCTCCTCACCCTTA
Downstream sequence
GTGCCATTGTGGATTTCTCTCTTGTTTGATTGCAGATCttttttttttttttttttttGCCTTTGGCATCATGGTGAACTTCTCTTGGGAAGGACTGCAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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